Tau filaments in neurodegenerative diseases

Intermediate Filaments in Neurodegenerative Diseases

Tau mutations in neurodegenerative diseases.

Tau deposition is found in a variety of neurodegenerative brain diseases. The identification of tau mutations that cause familial dementia demonstrated that aberrant Tau alone could cause neurodegenerative disease and suggested that Tau likely plays a role in other cases in which Tau deposits are found, most notably Alzheimer disease. The mechanisms by which tau mutations cause neurodegeneratio...

Tau as a biomarker of neurodegenerative diseases.

The microtubule-associated protein Tau is mainly expressed in neurons of the CNS and is crucial in axonal maintenance and axonal transport. The rationale for Tau as a biomarker of neurodegenerative diseases is that it is a major component of abnormal intraneuronal aggregates observed in numerous tauopathies, including Alzheimer's disease. The molecular diversity of Tau is very useful when analy...

Tau as biomarker of neurodegenerative diseases

1. Inserm, U837, place de Verdun, 59045 Lille, France. 2. Université de Lille 2, Faculté de Médecine, Institut de Médecine prédictive et de Recherche thérapeutique, Centre de Recherches Jean-Pierre Aubert, place de Verdun, 59045 Lille, France. 3. Institut de Biochimie, Centre hospitalier universitaire, UF de Neurobiologie, Lille, France. 4. Innogenetics NV, Industriepark Zwijnaarde 7, 9052 Gent...

The Importance of Tau Phosphorylation for Neurodegenerative Diseases

Fibrillar deposits of highly phosphorylated tau are a key pathological feature of several neurodegenerative tauopathies including Alzheimer's disease (AD) and some frontotemporal dementias. Increasing evidence suggests that the presence of these end-stage neurofibrillary lesions do not cause neuronal loss, but rather that alterations to soluble tau proteins induce neurodegeneration. In particul...